Resurfacing work is due to start on Monday on the B1112 Feltwell Road at Hockwold.
The major roadworks scheme, costing around £360,000, will take two weeks to complete, subject to the weather.
It will extend from the junction with Malts Lane through to the entrance to RAF Feltwell. The road will be closed overnight from 7pm to 6am.
A spokesman for Norfolk County Council said the road would be closed to all through traffic during this time and vehicles would be diverted.
“Vehicle access to businesses and homes within the limits of the works will be maintained from one end of the closure at any time,” the spokesman added.
The work will be carried out by the council’s community and environmental services department and its contractors.